14 Recognisable Vitamin Toxicity Symptoms, Side Effects And Treatments!

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Published on: 02-May-2024

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14 Recognisable Vitamin Toxicity Symptoms, Side Effects And Treatments!

14 Recognisable Vitamin Toxicity Symptoms, Side Effects And Treatments!

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Excessive intake of vitamins, essential for maintaining optimal health, can sometimes lead to toxicity, presenting a range of symptoms and side effects. While vitamins are crucial for various bodily functions, their overconsumption can result in adverse effects, necessitating awareness and caution. From vitamin A to vitamin D, each has its own set of toxicity symptoms, ranging from mild discomfort to severe complications, prompting the need for proper understanding and management. 

Even though vitamin toxicity is common, it is not healthy to overdose on vitamins. According to the national statistics on nutrition and overdose, in 2021, 42,784 toxic exposures were reported in children worldwide. Fortunately, in most cases, this does not result in serious medical consequences. Therefore, adequate vitamin intake depends on your age and overall health. Certain life events like pregnancy or recovery can also affect your vitamin requirements.   

Identifying specific vitamin toxicity symptoms is essential for timely intervention and treatment. Whether it's vitamin C causing gastrointestinal disturbances or vitamin D leading to calcium buildup and organ damage, recognising these signs allows for targeted therapies. So, to help you learn about vitamin toxicity symptoms, this blog explores specific vitamin overdose symptoms with recommended daily intake criteria to gain the benefits of vitamins. 

Table Of Contents 

1. What Is Vitamin Toxicity? 

2. 14 Specific Vitamin Toxicity Symptoms 

3. Side Effects Of Overdose On Vitamins 

4. Vitamin Toxicity Treatment 

5. Dietitian’s Recommendation 

6. The Final Say 

7. FAQs 

8. References 

What Is Vitamin Toxicity? 

Vitamin toxicity, or hypervitaminosis, is an abnormal condition caused by high vitamin levels in the body. It occurs when you consume too many of the two types of vitamins, water-soluble and fat-soluble, essential nutrients needed to keep your body healthy. Fat-soluble vitamins are not easily excreted from the body, increasing the risk of vitamin toxicity. This can be caused by improper use of vitamin supplements, certain medications and their interaction or diseases.  

  • Water-soluble vitamins: Vitamins such as C and B are soluble in water. The body uses what it needs and eliminates the rest through urine, making it difficult to reach toxic levels. However, large doses may still cause digestive problems or interfere with treatment.   

  • Fat-soluble vitamins: Vitamins A, D, E, and K are stored in fat. If you consistently consume more than your body needs, it can build up quickly and cause potentially serious side effects.   

Most people will benefit from following their recommended daily intake (RDI), which is the amount of vitamins you should consume daily to stay healthy. This will help keep your vitamin levels healthy. People with vitamin deficiencies are advised not to consume more than the safe upper limit and should only follow the professional advice of a nutritionist or similarly qualified doctor.  

Note: The safe upper limit (UL) Is the maximum amount of a vitamin that a person can consume without side effects. This is the maximum amount you can consume daily to avoid toxicity.  

14 Specific Vitamin Toxicity Symptoms 


Symptoms of vitamin overdose depend on the type of vitamin and the severity of toxicity. Common symptoms of vitamin overdose include:   

1. Vitamin A Overdose Symptoms 

Vitamin A is essential for vision, immune function, and cell growth. Symptoms of an overdose of vitamin A include nausea, vomiting, loss of appetite, dizziness, blurred vision or double vision, bone pain, joint stiffness and swelling, arrhythmia, hair loss, headache, temporary loss of consciousness, irritability, abdominal pain, fever, skin rash, dry areas, cracked lips, and brittle nails. Hypervitaminosis A during pregnancy can cause birth defects in the fetus. 

Dosage and Notes: 

  • Vitamin A is found in high doses, up to 180,000 IU per gram, in fish oil. Supplements may contain 10,000 to 50,000 IU.   

  • Recommended daily dose: 900 mcg (3000 IU) for men and 700 mcg (2333 IU) for women.   

  • Upper Limit: 3000 mcg (10,000 IU)   

2. Vitamin D Overdose Symptoms 

It helps promote calcium absorption, promotes bone health and supports immune function. Symptoms of an overdose of vitamin D include hypercalcemia, nausea, weakness, vomiting, confusion, kidney damage, tremors in the extremities, severe pain in the extremities and back muscles, dehydration, bleeding under the skin (haemorrhage), bone deformities during pregnancy, risk of pancreatic cancer, cardiovascular disease. These include the risk of falls and fractures in older adults and tooth enamel overgrowth in children.   

Dosage and Notes: 

  • Sunlight does not cause hypervitaminosis D. Taking high doses of calcium (via supplements or fortified foods) and vitamin D supplements may cause hypervitaminosis D. 

  • Vitamin A may protect the kidneys from the toxic effects of vitamin D overdose.   

  • Recommended daily dose: 15 mcg (600 IU) for most adults, below which there will be vitamin D deficiency and 20 mcg (800 IU) for those over 70.   

  • Upper Limit: 100 mcg (10,000 IU)   

3. Vitamin E Overdose Symptoms 

Vitamin E acts as an antioxidant, protects cells from damage, and plays a vital role in immune function. Symptoms of an overdose of vitamin E include weakness, fatigue, headache, diarrhoea, intestinal cramps, and delayed wound healingAdditionally, taking it with blood thinners may increase bleeding and cardiovascular symptoms such as high blood pressure, angina, and atherosclerotic plaques.   

Dosage and Notes: 

  • Recommended daily dose: 15mg   

  • Upper Limit: 1000 mg (1500 IU)   

4. Vitamin K Overdose Symptoms 

Vitamin K is essential for blood clotting factor production and the best way to improve your bone health. Symptoms of vitamin K overdose include an increased risk of blood clots. Most forms of vitamin K (K1 and K2) are safe. Vitamin K3 is toxic and is not sold as a supplement.   

Dosage and Notes: 

  • Recommended daily dose: 120 mcg for men and 90 mcg for women.   

  • No upper limit listed   

5. B1 (Thiamine) Overdose Symptoms 

It promotes nerve function and helps convert food into energy. Although an overdose of vitamin B1 is generally safe, severe toxicity can cause decreased nerve transmission, paralysis, seizures, and respiratory and heart problems. It can affect the metabolism of other B vitamins, insulin signalling, and thyroid function.    

Dosage and Notes: 

  • Recommended daily dose: 1.2 mg for men, 1.1 mg for women.   

  • No upper limit listed   

6. B2 (Riboflavin) Overdose Symptoms 

Vitamin B12 is essential for energy production and cellular processes. Excessive intake of vitamins may cause liver dysfunction, photophobia, dry mouth, cardiomyopathy, vomiting, itching, numbness, burning, low blood pressure, fatigue, and yellow urine.   

Dosage and Notes: 

  • Recommended daily dose: 1.3 mg for men, 1.1 mg for women.   

  • No upper limit listed   

7. B3 (Niacin) Overdose Symptoms 

It helps with energy metabolism and DNA repair and maintains healthy cholesterol levels. High doses may cause facial flushing, skin redness, nausea, and potential liver damage. Liver toxicity, low blood pressure, dizziness, insomnia, peptic ulcers, skin rash, flushing, itching, digestive problems, exacerbation of asthma, gout and high blood sugar.   

Dosage and Notes: 

  • Recommended daily dose: 16 mg for men and 14 mg for women.   

  • Upper Limit: 35mg   

8. B5 (pantothenic acid) Overdose Symptoms 

It is essential for hormones and other vital compounds. Overdose may cause diarrhoea, upset stomach, fluid retention, and oedema (oedema)  

Dosage and Notes: 

  • Recommended daily dose: 5mg   

  • No upper limit listed   

9. B6 (Pyridoxine) Overdose Symptoms 

It is essential in red blood cell production, brain function, and neurotransmitter synthesis. Long-term use of high doses of supplements (300-500 mg/day) may cause sensory neuropathy, ataxia, skin rash, photosensitivity, nausea, and heartburn. At higher doses, symptoms worsen, causing nerve damage, paresthesia, difficulty walking, fatigue, and decreased tactile sensitivity.   

Dosage and Notes: 

  • Recommended daily dose: 1.3 mg for adults under 50 years of age, 1.7 mg for men over 50 years of age, and 1.5 mg for women over 50 years of age.   

  • Upper Limit: 100mg   

10. B7 (Biotin) Overdose Symptoms 

It is one of the essential nutrients in foods for healthy hair, helps maintain nails and skin and is involved in energy metabolism. It is generally considered safe. Sometimes, overdosage results in hyperkeratosis (extremely thick areas of skin).   

Dosage and Notes: 

  • Recommended daily dose: 30 mcg   

  • No upper limit listed   

11. B9 (Folic Acid) Overdose Symptoms 

It is essential for DNA synthesis, cell division, and red blood cell formation. Severe toxicity may cause stomach muscle spasms, suppressed liver enzymes, sleeping problems, gastrointestinal problems, and skin problems. High doses may mask B12 deficiency. The excess is mainly caused by synthetic folic acid.   

Dosage and Notes: 

  • Recommended daily dose: 400 mcg   

  • Upper Limit: 1000mcg   

12. B12 (cobalamin) Overdose Symptoms 

It is essential to the best brain foods for nervous system function, brain health, and red blood cell production. However, an overdose may interact with some medications. High-dose injections for anaemia in older adults can cause allergic reactions, heart problems, tingling, and numbness.    

Dosage and Notes: 

  • Recommended daily dose: 2.4 mcg   

  • No upper limit listed   

13. B Complex Vitamin Overdose Symptoms 

It contains all the B vitamins essential for good health. Symptoms of an overdose of vitamin B complex include skin irritation, headache, intestinal ulcers, sleeping problems, fatty liver, high blood sugar and uric acid levels, nausea, and stomach upset.   

Dosage and Notes: 

  • Recommended daily dose of vitamin B complex varies by person: 

  • Young adults: 400 micrograms (mcg) daily 

  • Lactating mothers: 500 mcg a day 

  • Pregnant women and older adults: 600 mcg a day 

  • No upper limit is listed. 

14. Vitamin C Overdose Symptoms 

A powerful antioxidant that promotes collagen production and wound healing and supports immune function. Symptoms of an overdose of vitamin C-rich foods or supplements include weakness, dizziness, diarrhoea, nausea, vomiting, insomnia, headache, allergic reaction, etc. Serious effects include kidney disease, gastritis, stomach ulcers, vitamin B deficiency, pancreatic problems, high blood pressure, blurred vision, menstrual irregularities, decreased white blood cell count, and hormonal disorders. It can also cause oxalate buildup and kidney stones and harm the fetus's metabolism during pregnancy.    

Dosage and Notes: 

  • Recommended daily dose: 90 mg for men and 75 mg for women.   

  • Upper Limit: 2000mg  

Side Effects Of Overdose On Vitamins 

Both water-soluble and fat-soluble vitamins can cause side effects when taken in high doses.   

1. Side Effects From Overdose Of Water-Soluble Vitamins   

Overdosing on the following water-soluble vitamins may cause the following side effects:   

Water-Soluble Vitamin 

Overdose Side Effects 

Impact 

Prevention Tips 

Vitamin C 

Diarrhoea, nausea, cramps, vomiting, migraines 

High doses may lead to gastrointestinal discomfort and headaches. 

Stick to recommended daily intake levels and obtain vitamin C from natural sources like fruits and vegetables rather than supplements. 

Vitamin B3 

High blood pressure, blurred vision, liver damage, abdominal pain 

Excessive intake can cause liver toxicity and cardiovascular issues. 

Consult a doctor before taking high doses of niacin supplements, and monitor liver function regularly if necessary. 

Vitamin B9 

Harm to the immune system's mental function 

Excessive folic acid intake may mask symptoms of vitamin B12 deficiency. 

Vitamin B9 (folic acid) can be obtained through dietary sources like leafy greens and legumes, and only supplements should be taken under the guidance of your doctor. 

Vitamin B6 

Nausea, heartburn, skin lesions, sensitivity to light, serious neurological symptoms 

Prolonged overdose can lead to irreversible nerve damage. 

Avoid mega-doses of vitamin B6 supplements and focus on obtaining it through a balanced diet, including meat, fish, whole grains, and nuts. 

2. Side Effects From Overdose Of Fat-Soluble Vitamins   

In addition to vitamin K, which has a low toxicity potential, other fat-soluble vitamins may cause the following side effects:   

Fat-Soluble Vitamin 

Overdose Side Effects 

Impact 

Prevention Tips 

Vitamin A 

Vision changes, hair loss, high intracranial pressure, nausea, coma, death 

Excessive intake can lead to severe toxicity and potentially fatal outcomes. 

Avoid consuming high-dose vitamin A supplements and be cautious about consuming animal liver, which is rich in vitamin A. 

Vitamin D 

Loss of appetite, weight loss, kidney stones, irregular heartbeat, increased blood calcium levels, organ damage 

Overdose can result in hypercalcemia and serious complications. 

Take vitamin D supplements only under medical supervision and adhere to recommended dosage guidelines.  

Vitamin E 

Interference with blood clotting, hemorrhagic stroke 

Excessive intake can disrupt normal blood coagulation processes. 

Obtain vitamin E primarily from dietary sources like nuts, seeds, and vegetable oils, and avoid high-dose supplementation unless prescribed by a healthcare professional. 

Vitamin Toxicity Treatment 

Treatment of vitamin toxicity is generally supportive and symptomatic. Note the following recommended guidelines: 

Vitamin 

Treatment of Toxicity 

Considerations 

Vitamin A 

Supportive and symptomatic treatment, GI tract cleansing, charcoal for acute overdose, reduced intake, medication for severe symptoms 

Acute toxicity often follows a single large dose. Chronic toxicity may require ongoing management. 

Vitamin D 

Supportive treatment, stop intake, hydration, steroids, diuretics, mithramycin, calcitonin for severe cases 

Blood and urine tests are used for diagnosis. Severe hypercalcemia may necessitate aggressive treatment. 

Vitamin B6 

Discontinue supplement intake, monitor symptoms, and consult a doctor if symptoms persist. 

Symptoms usually resolve upon stopping supplementation. Avoid excessive intake to prevent toxicity. 

However, do not consume more vitamins than recommended through food and supplements. This action serves to prevent vitamin toxicity. If your symptoms do not improve after reducing your vitamin intake, contact your doctor to plan a diagnosis and treatment.  

Dietitian’s Recommendation 

Vitamins are essential for your health, and more is not necessarily better. Overdosing in fat-soluble and water-soluble vitamins can have disastrous consequences. To avoid side effects, follow recommended vitamin and mineral intakes to prevent overdose. Consult your doctor before taking any vitamin supplements, especially in high doses. When taking multivitamins, fortified foods, or individual supplements, be careful not to exceed safe levels. If you suspect a vitamin overdose, call your doctor right away to manage your symptoms and prevent complications.  

Dt. Lavina Chauhan 

The Final Say 

Hopefully, you have understood that vitamin toxicity is a severe condition that can negatively affect your health. It is essential to follow the daily dosage recommendations to not overdose on vitamins, follow essential eating well guidelines and consult your doctor before taking any supplement. If you suspect that you or someone you know has overdosed on a vitamin, seek medical attention immediately. With proper prevention and treatment, you can stay safe and enjoy the benefits of all 13 essential vitamins for your well-being.    

FAQs 

1. What are the symptoms of vitamin poisoning? 
Symptoms of vitamin poisoning can vary depending on the specific vitamin and the severity of the overdose. Common symptoms include nausea, vomiting, abdominal pain, headache, fatigue, and, in severe cases, organ damage or failure. 

2. What is the best vitamin overdose treatment for toxicity side effects relief? 
The treatment for vitamin overdose toxicity typically involves supportive and symptomatic care. This may include discontinuing vitamin supplements, cleansing the gastrointestinal tract, and using medications such as activated charcoal or antiemetics to reduce absorption and alleviate symptoms. In severe cases, medical interventions such as hydration, steroids, or diuretics may be necessary. 

3. Can you tell which vitamins can cause toxicity? 
Excessive fat-soluble vitamins A, D, E, and K intake can lead to toxicity. However, specific water-soluble vitamins, such as vitamin B6 and niacin (B3), can also cause toxicity if consumed in large amounts over an extended period. 

4. What are the symptoms of vitamin B12 poisoning? 
High levels of vitamin B12 can cause various symptoms, including anxiety, acne, nausea, headaches, facial numbness, insomnia, heart palpitations, and, in rare cases, heart stroke. It's essential to monitor intake levels and consult a healthcare professional if experiencing any adverse effects. 

5. What is the treatment for vitamin poisoning? 
Treatment for vitamin toxicity involves discontinuing the intake of the specific vitamin causing the overdose. Supportive measures such as cleansing the gastrointestinal tract, using activated charcoal, or administering medications like laxatives or antiemetics may be employed to alleviate symptoms. Medical intervention and close monitoring are necessary to diagnose and treat severe cases appropriately 

References 

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